Inventi Rapid: Med Chem

Inventi:prmc/79019/24

Synthesis and Derivatives and Their Quantitative Analysis with Pharmacological Evaluation on Antipsychotic Activity

A series of new benzimidazole derivatives having central benzimidazole ring along with piperazine nucleus and substituents as chloro, and methyl at different positions of imidazole as well as piperazine ring were synthesized which have been design as PZ1, PZ2, PZ3, PZ4 on the basis of result findings and discussion of the literature available which suggest the possibilities of Piperazine with benzimidazole ring having different lipophilic substitution on it. All the synthesized compounds were screened for their antipsychotic activity in Foot Shock- Induced Aggression (FSIA) in S targeted compound and Lithium- Induced Head Twitches models and were compared with standard drugs phenytoin sodium and sodium valproate. Pharmacological evaluation shows that the antipsychotic activities are quite well predicted as per the previous research available. Thus, the derivatives can be potentially explored for further studies....